Synthesis And Characterization Of Some Metal Complexes Of Zn(II) With 1,10- Phenanthroline And Some Amino Acids: Anti-Inflammatory And Analgesic Activities Of Its Complexes

New mixed ligand complexes of Zn(II) with 1,10Phenanthroline and some amino acids were prepared in the solid form and characterized by elemental analysis, conductivity, magnetic moment measurement, FT-IR, 1 H-NMR, 13 C-NMR and FAB+ mass studies. To examine anti-inflammatory and analgesic activities of its complexes, some Swiss albino mice of 05-07 weeks old were taken. One dose of the test compounds of 10 mg/kg was selected throughout the research work. The anti-inflammatory activity of the test compounds were determined by ‘carragenan induced mice paw edema inhibition’ method, and however, the analgesic activity was determined by ‘acetic acid induced writhing’ methods. These four compounds showed positive effects as anti-inflammatory and analgesic agents. Anti-inflammatory and analgesic activities of the test compounds at 50 mg/kg were quite comparable to those of standard drugs at 10 mg/kg. Keywards: Zinc, amino acids, 1,10-Phenanthroline, anti-inflammatory and analgesic activity, 1 H-NMR, 13 C-NMR and FAB+ mass ————————————————————